Recombinant Human Caspase recruitment domain-containing protein 16 (CARD16)

Uniprot Id

Q5EG05

Target Species

Human

Target Name

CARD16

Target Full Name

Caspase recruitment domain-containing protein 16

Target Function

Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.

Target Tissue Specificity

Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus.

Target Synonyms

CAR16_HUMAN; CARD only domain-containing protein 1; CARD only protein ; CARD16; Caspase recruitment domain family, member 16; Caspase recruitment domain-containing protein 16; Caspase-1 dominant-negative inhibitor pseudo-ICE ; Caspase-1 inhibitor COP; COP; COP1; Pseudo interleukin 1 beta converting enzyme; Pseudo interleukin-1 beta converting enzyme; Pseudo interleukin-1beta converting enzyme ; PSEUDO-ICE

Target Background

Enables several functions, including CARD domain binding activity; cysteine-type endopeptidase inhibitor activity; and enzyme binding activity. Involved in several processes, including negative regulation of cysteine-type endopeptidase activity; regulation of gene expression; and regulation of signal transduction. Part of protease inhibitor complex.