Recombinant Human Chemokine-like protein TAFA-5 (TAFA5)

Uniprot Id

Q7Z5A7

Target Species

Human

Target Name

TAFA5

Target Full Name

Chemokine-like protein TAFA-5

Target Function

Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2. Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway. Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes. Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2. Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling. Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries

Target Subcellular Location

Secreted.

Target Protein Families

FAM19/TAFA family

Target Tissue Specificity

Expressed in the subcutaneous and perirenal adipose tissue (at protein level). Highly expressed in adipose tissue with moderate expression in the brain and ovary. Isoform 2: Brain-specific.

Target Synonyms

TAFA5; FAM19A5; UNQ5208/PRO34524; Chemokine-like protein TAFA-5