Recombinant Human Chromatin modification-related protein MEAF6 (MEAF6)

Uniprot Id

Q9HAF1

Target Species

Human

Target Name

MEAF6

Target Full Name

Chromatin modification-related protein MEAF6

Target Function

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.

Target Involvement

A chromosomal aberration involving MEAF6 may be a cause of endometrial stromal tumors. Translocation t(1;6)(p34;p21) with PHF1.

Target Subcellular Location

Nucleus, nucleolus. Chromosome, centromere, kinetochore.

Target Protein Families

EAF6 family

Target Synonyms

MEAF6; C1orf149; CENP-28; EAF6Chromatin modification-related protein MEAF6; MYST/Esa1-associated factor 6; Esa1-associated factor 6 homolog; Protein EAF6 homolog; hEAF6; Sarcoma antigen NY-SAR-91

Target Background

This gene encodes a nuclear protein involved in transcriptional activation. The encoded protein may form a component of several different histone acetyltransferase complexes. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in multiple transcript variants.