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Recombinant Human Chromodomain-helicase-DNA-binding protein 4 (CHD4), Truncated

ACP04872

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Specifications

Cat.No	ACP04872	Target Name	CHD4
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	1-239aa	Mol Weight	31.8 kDa
Protein Length	Partial	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q14839

Background Information

Uniprot Id

Q14839
Target Species

Human
Target Name

CHD4
Target Full Name

Chromodomain-helicase-DNA-binding protein 4
Target Function

Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones.
Target Involvement

Sifrim-Hitz-Weiss syndrome (SIHIWES)
Target Subcellular Location

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Target Protein Families

SNF2/RAD54 helicase family
Target Research Area

Epigenetics and Nuclear Signaling
Target Synonyms

ATP dependent helicase CHD4; ATP-dependent helicase CHD4; CHD 4; CHD-4; CHD4; CHD4_HUMAN; Chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4; Mi 2 autoantigen 218 kDa protein; Mi 2b; Mi-2 autoantigen 218 kDa protein; Mi2 beta; Mi2-beta
Target Background

The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Recombinant Human Chromodomain-helicase-DNA-binding protein 4 (CHD4), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Chromodomain-helicase-DNA-binding protein 4 (CHD4), Truncated Now

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