Recombinant Human Cip1-interacting zinc finger protein (CIZ1), Truncated

Uniprot Id

Q9ULV3

Target Species

Human

Target Name

CIZ1

Target Full Name

Cip1-interacting zinc finger protein

Target Function

May regulate the subcellular localization of CIP/WAF1.

Target Involvement

Defects in CIZ1 may be a cause of adult onset primary cervical dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Cervical dystonia or spasmodic torticollis, the most common form of focal dystonia, is characterized by involuntary contractions of the neck muscles, which produce abnormal posturing of the head upon the trunk.

Target Subcellular Location

Nucleus.

Target Synonyms

CDKI; CDKN1A-interacting zinc finger protein 1; Cip1-interacting zinc finger protein; CIZ1; CIZ1_HUMAN; cyclin dependent inhibitor 1A; LSFR1; Melanoma differentiation-associated protein; NP94; Nuclear protein NP94; OPHN3; P21; Zinc finger protein 356; ZNF356

Target Background

The protein encoded by this gene is a zinc finger DNA binding protein that interacts with CIP1, part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1. Several transcript variants encoding different isoforms have been found for this gene.