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| Cat.No | ACP12874 | Target Name | CCDC115 |
|---|---|---|---|
| Target Synonyms | CCDC115Coiled-coil domain-containing protein 115 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-180 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96NT0 |
|---|
Uniprot Id
Q96NT0
Target Species
Human
Target Name
CCDC115
Target Full Name
Coiled-coil domain-containing protein 115
Target Function
Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis.
Target Involvement
Congenital disorder of glycosylation 2O (CDG2O)
Target Subcellular Location
Endosome. Lysosome. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle, COPI-coated vesicle. Endoplasmic reticulum.
Target Tissue Specificity
Expressed throughout the brain.
Target Synonyms
CCDC115Coiled-coil domain-containing protein 115
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