Recombinant Human Coiled-coil domain-containing protein 88B (CCDC88B), Truncated

Uniprot Id

A6NC98

Target Species

Human

Target Name

CCDC88B

Target Full Name

Coiled-coil domain-containing protein 88B

Target Function

Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation. Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC. Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis

Target Subcellular Location

Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center. Endoplasmic reticulum. Golgi apparatus. Cytoplasm.

Target Protein Families

CCDC88 family

Target Tissue Specificity

Expressed in endothelium (at protein level). Expressed in NK cells (at protein level).

Target Synonyms

Brain leucine zipper domain containing protein; Brain leucine zipper domain-containing protein; Brain leucine zipper protein; BRLZ; CC88B_HUMAN; CCDC 88; CCDC 88B; Ccdc88b; Coiled coil domain containing 88; Coiled coil domain containing protein 88B; Coiled-coil domain-containing protein 88B; DKFZp434G0920; FLJ00354; FLJ37970; HkRP 3; HkRP3; Hook related protein 3; Hook-related protein 3