Recombinant Human Coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial (CHCHD2)

Cat.No	ACP09420	Target Name	CHCHD2
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-151	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP09420

Target Name

CHCHD2

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-151

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9Y6H1

Background Information

Uniprot Id

Q9Y6H1
Target Species

Human
Target Name

CHCHD2
Target Full Name

Coiled-coil-helix-coiled-coil-helix domain-containing protein 2
Target Function

Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen).
Target Involvement

Parkinson disease 22 (PARK22)
Target Subcellular Location

Nucleus. Mitochondrion. Mitochondrion intermembrane space.
Target Synonyms

16.7kD protein; Aging Associated Gene 10 Protein; Aging-associated gene 10 protein; C7orf17; CHCH2_HUMAN; CHCHD 2; CHCHD2; Coiled Coil Helix Coiled Coil Helix Domain Containing 2; Coiled coil helix coiled coil helix domain containing protein 2; mitochondrial; Coiled-coil-helix-coiled-coil-helix domain-containing protein 2; mitochondrial; HCV NS2 trans regulated protein; HCV NS2 trans-regulated protein; NS2TP
Target Background

The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants.

Recombinant Human Coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial (CHCHD2)

Specifications

Immunogen Information

Inquire Recombinant Human Coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial (CHCHD2) Now

Related Products