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| Cat.No | ACP12993 | Target Name | CPLX3 |
|---|---|---|---|
| Target Synonyms | CPLX3; Nbla11589Complexin-3; Complexin III; CPX III | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-155 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8WVH0 |
|---|
Uniprot Id
Q8WVH0
Target Species
Human
Target Name
CPLX3
Target Full Name
Complexin-3
Target Function
Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion. Required for the maintenance of synaptic ultrastructure in the adult retina. Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina. Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release.
Target Subcellular Location
Cell junction, synapse. Cell membrane; Lipid-anchor.
Target Protein Families
Complexin/synaphin family
Target Synonyms
CPLX3; Nbla11589Complexin-3; Complexin III; CPX III
Target Background
Predicted to enable SNARE binding activity. Predicted to be involved in regulation of neurotransmitter secretion and synaptic vesicle exocytosis. Predicted to be located in plasma membrane and synapse. Predicted to be part of SNARE complex. Predicted to be active in photoreceptor ribbon synapse and terminal bouton. Predicted to be anchored component of presynaptic active zone membrane and anchored component of synaptic vesicle membrane.
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