Recombinant Human Coxsackievirus and adenovirus receptor (CXADR), Truncated

Cat.No	ACP06591	Target Name	CXADR
Target Synonyms	CXADR; CAR; Coxsackievirus and adenovirus receptor; hCAR; CVB3-binding protein; Coxsackievirus B-adenovirus receptor; HCVADR	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP06591

Target Name

CXADR

Target Synonyms

CXADR; CAR; Coxsackievirus and adenovirus receptor; hCAR; CVB3-binding protein; Coxsackievirus B-adenovirus receptor; HCVADR

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P78310

Background Information

Uniprot Id

P78310
Target Species

Human
Target Name

CXADR
Target Full Name

Coxsackievirus and adenovirus receptor
Target Function

Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.; (Microbial infection) Acts as a receptor for adenovirus type C.; (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6.
Target Subcellular Location

[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Cell junction, adherens junction.; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.; [Isoform 5]: Secreted.
Target Tissue Specificity

Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromusc
Target Synonyms

CXADR; CAR; Coxsackievirus and adenovirus receptor; hCAR; CVB3-binding protein; Coxsackievirus B-adenovirus receptor; HCVADR
Target Background

The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21.

Recombinant Human Coxsackievirus and adenovirus receptor (CXADR), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Coxsackievirus and adenovirus receptor (CXADR), Truncated Now

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