Recombinant Human CUGBP Elav-like family member 5 (CELF5)

Uniprot Id

Q8N6W0

Target Species

Human

Target Name

CELF5

Target Full Name

CUGBP Elav-like family member 5

Target Function

RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.

Target Subcellular Location

Nucleus. Cytoplasm.

Target Protein Families

CELF/BRUNOL family

Target Tissue Specificity

Expressed in brain.

Target Synonyms

CELF5; BRUNOL5CUGBP Elav-like family member 5; CELF-5; Bruno-like protein 5; CUG-BP- and ETR-3-like factor 5; RNA-binding protein BRUNOL-5

Target Background

This gene encodes a member of the the CELF/BRUNOL protein family, which contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing and translation. Alternatively spliced transcript variants have been found for this gene.