Recombinant Human Cysteine and glycine-rich protein 2 (CSRP2)

Uniprot Id

Q16527

Target Species

Human

Target Name

CSRP2

Target Full Name

Cysteine and glycine-rich protein 2

Target Function

Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Highly expressed in the aorta, but not in heart and skeletal muscle.

Target Synonyms

CRP2; CSRP2; CSRP2_HUMAN; Cysteine and glycine rich protein 2; Cysteine and glycine-rich protein 2; Cysteine rich protein 2; Cysteine-rich protein 2; LIM domain only protein 5; LMO-5; LMO5; SmLIM; Smooth muscle cell LIM protein

Target Background

CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. Alternative splicing results in multiple transcript variants.