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| Cat.No | ACP17425 | Target Name | CYP27C1 |
|---|---|---|---|
| Target Synonyms | C27C1_HUMAN; CYP27C1; Cytochrome P450 27C1; Cytochrome P450 family 27 subfamily C polypeptide 1; Cytochrome P450 family 27 subfamily C polypeptide 13; FLJ16008 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-372 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q4G0S4 |
|---|
Uniprot Id
Q4G0S4
Target Species
Human
Target Name
CYP27C1
Target Full Name
Cytochrome P450 27C1
Target Function
A cytochrome P450 monooxygenase that catalyzes the 3,4 desaturation of all-trans-retinol (also called vitamin A1) to all-trans-3,4-didehydroretinol (also called vitamin A2) in the skin. Desaturates with lower efficiency all-trans retinal and all-trans retinoic acid. Forms minor amounts of 3-hydroxy and 4-hydroxy all-trans-retinol derivatives. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin)
Target Subcellular Location
[Isoform 2]: Mitochondrion membrane; Peripheral membrane protein.
Target Protein Families
Cytochrome P450 family
Target Tissue Specificity
Widely expressed, with highest levels in the liver, kidney and pancreas.; [Isoform 2]: Expressed in the skin (at protein level).
Target Synonyms
C27C1_HUMAN; CYP27C1; Cytochrome P450 27C1; Cytochrome P450 family 27 subfamily C polypeptide 1; Cytochrome P450 family 27 subfamily C polypeptide 13; FLJ16008
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