Recombinant Human Cytochrome P450 3A7 (CYP3A7)

Cat.No	ACP04902	Target Name	CYP3A7
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-503	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP04902

Target Name

CYP3A7

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-503

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P24462

Background Information

Uniprot Id

P24462
Target Species

Human
Target Name

CYP3A7
Target Full Name

Cytochrome P450 3A7
Target Function

A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA), a precursor in the biosynthesis of androgen and estrogen steroid hormones. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position. Mainly hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in atRA clearance during fetal development. Also involved in the oxidative metabolism of xenobiotics including anticonvulsants.
Target Subcellular Location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Target Protein Families

Cytochrome P450 family
Target Tissue Specificity

Expressed in fetal liver (at protein level).
Target Research Area

Cardiovascular
Target Synonyms

Aryl hydrocarbon hydroxylase; CP37; CP3A7_HUMAN; CYP3A7; CYPIIIA7; Cytochrome P450 3A7; Cytochrome P450; family 3; subfamily A; polypeptide 7; Cytochrome P450; subfamily IIIA; polypeptide 7; Cytochrome P450-HFLA; Flavoprotein linked monooxygenase; Flavoprotein-linked monooxygenase; Microsomal monooxygenase; P 450(HFL33); P 450111A7; P450 HFLA; Xenobiotic monooxygenase

Recombinant Human Cytochrome P450 3A7 (CYP3A7)

Specifications

Immunogen Information

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