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| Cat.No | ACP13951 | Target Name | AGBL5 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8NDL9 |
|---|
Uniprot Id
Q8NDL9
Target Species
Human
Target Name
AGBL5
Target Full Name
Cytosolic carboxypeptidase-like protein 5
Target Function
Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation.
Target Involvement
Retinitis pigmentosa 75 (RP75)
Target Subcellular Location
Cytoplasm, cytosol. Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody.
Target Protein Families
Peptidase M14 family
Target Tissue Specificity
Expressed in brain.
Target Synonyms
AGBL5; ATP/GTP binding protein like 5; ATP/GTP-binding protein-like 5; CBPC5_HUMAN; CCP5; Cytosolic carboxypeptidase like protein 5; Cytosolic carboxypeptidase-like protein 5; FLJ21839; Hypothetical protein FLJ21839
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