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| Cat.No | ACP13820 | Target Name | DOCK10 |
|---|---|---|---|
| Target Synonyms | DOCK10; KIAA0694; ZIZ3Dedicator of cytokinesis protein 10; Zizimin-3 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96BY6 |
|---|
Uniprot Id
Q96BY6
Target Species
Human
Target Name
DOCK10
Target Full Name
Dedicator of cytokinesis protein 10
Target Function
Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.
Target Subcellular Location
Nucleus. Cytoplasm. Cell projection, dendritic spine.
Target Protein Families
DOCK family
Target Tissue Specificity
Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells.
Target Synonyms
DOCK10; KIAA0694; ZIZ3Dedicator of cytokinesis protein 10; Zizimin-3
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