Recombinant Human Dematin (DMTN)

Cat.No	ACP18607	Target Name	DMTN
Target Synonyms	DEMA; DEMA_HUMAN; Dematin; DMT; EPB49; erythrocyte membrane protein band 4.9 (dematin) ; Erythrocyte membrane protein band 4.9	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-405
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP18607

Target Name

DMTN

Target Synonyms

DEMA; DEMA_HUMAN; Dematin; DMT; EPB49; erythrocyte membrane protein band 4.9 (dematin) ; Erythrocyte membrane protein band 4.9

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-405

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q08495

Background Information

Uniprot Id

Q08495
Target Species

Human
Target Name

DMTN
Target Full Name

Dematin
Target Function

Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.
Target Subcellular Location

Cytoplasm. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane. Membrane. Endomembrane system. Cell projection. Note=Localized at the spectrin-actin junction of erythrocyte plasma membrane. Localized to intracellular membranes and the cytoskeletal network. Localized at intracellular membrane-bounded organelle compartment in platelets that likely represent the dense tubular network membrane. Detected at the cell membrane and at the parasitophorous vacuole in malaria-infected erythrocytes at late stages of plasmodium berghei or falciparum development.
Target Protein Families

Villin/gelsolin family
Target Tissue Specificity

Expressed in platelets (at protein level). Expressed in heart, brain, lung, skeletal muscle, and kidney.
Target Synonyms

DEMA; DEMA_HUMAN; Dematin; DMT; EPB49; erythrocyte membrane protein band 4.9 (dematin) ; Erythrocyte membrane protein band 4.9

Recombinant Human Dematin (DMTN)

Specifications

Immunogen Information

Inquire Recombinant Human Dematin (DMTN) Now

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