Recombinant Human DENN domain-containing protein 1B (DENND1B)

Uniprot Id

Q6P3S1

Target Species

Human

Target Name

DENND1B

Target Full Name

DENN domain-containing protein 1B

Target Function

Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Plays a role in clathrin-mediated endocytosis. Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity. Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells

Target Involvement

Asthma (ASTHMA)

Target Subcellular Location

Cytoplasm, cytosol. Cytoplasmic vesicle, clathrin-coated vesicle.

Target Tissue Specificity

Highly expressed in dendritic and natural killer cells and at lower levels in other myeloid lineage cells and in pituitary. Significantly up-regulated in effector memory T-cells as compared with naive T-cells.

Target Synonyms

C1ORF18; C1orf218 ; Chromosome 1 open reading frame 218; Connecdenn 2; DEN1B_HUMAN; DENN domain containing protein 1B; DENN domain-containing protein 1B; DENN MADD domain containing 1B; DENND1B; DKFZp547O0715; FAM31B ; Family with sequence similarity 31 member B; FLJ20054; FLJ21179 ; FLJ33888; MGC103810; MGC27044; Protein FAM31B; RP11 53I24.2