Recombinant Human Diacylglycerol kinase theta (DGKQ), Truncated

Uniprot Id

P52824

Target Species

Human

Target Name

DGKQ

Target Full Name

Diacylglycerol kinase theta

Target Function

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription. Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor. Through its diacylglycerol activity also regulates synaptic vesicle endocytosis.

Target Subcellular Location

Cytoplasm. Cytoplasm, cytosol. Cell membrane. Cell junction, synapse. Cytoplasm, cytoskeleton. Nucleus. Nucleus speckle. Nucleus matrix.

Target Protein Families

Eukaryotic diacylglycerol kinase family

Target Synonyms

DAG kinase theta; DAGK4; DAGK7; DGK theta; DGK-theta; Dgkq; DGKQ_HUMAN; Diacylglycerol kinase delta (110kD); Diacylglycerol kinase theta 110kDa; Diacylglycerol kinase theta; Diglyceride kinase theta

Target Background

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.