Recombinant Human Dihydropyrimidine dehydrogenase [NADP (+)] (DPYD), Truncated

Uniprot Id

Q12882

Target Species

Human

Target Name

DPYD

Target Full Name

Dihydropyrimidine dehydrogenase [NADP(+)]

Target Function

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.

Target Involvement

Dihydropyrimidine dehydrogenase deficiency (DPYDD)

Target Subcellular Location

Cytoplasm.

Target Protein Families

Dihydropyrimidine dehydrogenase family

Target Tissue Specificity

Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.

Target Synonyms

DHP; DHPDHase; Dihydropyrimidine dehydrogenase [NADP(+)]; Dihydropyrimidine dehydrogenase [NADP+]; Dihydropyrimidine dehydrogenase; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase; DPD; DPYD; DPYD_HUMAN; MGC132008; MGC70799; OTTHUMP00000058954

Target Background

The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene.