Recombinant Human Dimethyladenosine transferase 2, mitochondrial (TFB2M)

Uniprot Id

Q9H5Q4

Target Species

Human

Target Name

TFB2M

Target Full Name

Dimethyladenosine transferase 2, mitochondrial

Target Function

S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Stimulates transcription independently of the methyltransferase activity.

Target Subcellular Location

Mitochondrion.

Target Protein Families

Class I-like SAM-binding methyltransferase superfamily, rRNA adenine N(6)-methyltransferase family, KsgA subfamily

Target Tissue Specificity

Ubiquitously expressed.

Target Synonyms

N''-adenosyl(rRNA) dimethyltransferase 2; S adenosylmethionine 6 N', N' adenosyl(rRNA) dimethyltransferase 2; Dimethyladenosine transferase 2; dimethyladenosine transferase 2 mitochondrial; FLJ22661; FLJ23182; h mtTFB; h mtTFB2; h-mtTFB; h-mtTFB2; HCV NS5A transactivated protein 5; HCV NS5A-transactivated protein 5; hepatitis C virus NS5A transactivated protein 5; Hepatitis C virus NS5A-transactivated protein 5; Hkp1; hTFB2M; Mitochondrial 12S rRNA dimethylase 2; mitochondrial; Mitochondrial dimethyladenosine transferase 2; Mitochondrial transcription factor B2; mtTFB; mtTFB2; NS5ATP5; S-adenosylmethionine-6-N''; TFB2M; TFB2M_HUMAN; Transcription Factor B2; Transcription factor B2 mitochondrial