Recombinant Human DNA-binding protein RFX6 (RFX6), Truncated

Uniprot Id

Q8HWS3

Target Species

Human

Target Name

RFX6

Target Full Name

DNA-binding protein RFX6

Target Function

Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes. Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription.

Target Involvement

Mitchell-Riley syndrome (MTCHRS)

Target Subcellular Location

Nucleus.

Target Protein Families

RFX family

Target Tissue Specificity

Expressed in pancreas. Expressed in pancreatic beta-cells (insulin-positive cells) and alpha-cells (glucagon-positive cells) (at protein level). Specifically expressed in pancreas, small intestine and colon. Expressed in endocrine cells in the islets.

Target Synonyms

RFX6; RFXDC1; DNA-binding protein RFX6; Regulatory factor X 6; Regulatory factor X domain-containing protein 1