Recombinant Human DNA repair protein RAD52 homolog (RAD52)

Uniprot Id

P43351

Target Species

Human

Target Name

RAD52

Target Full Name

DNA repair protein RAD52 homolog

Target Function

Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.

Target Subcellular Location

Nucleus.

Target Protein Families

RAD52 family

Target Synonyms

DNA repair protein RAD52 ; DNA repair protein RAD52; DNA repair protein RAD52 homolog; RAD 52; Rad52; RAD52 homolog (S. cerevisiae) ; RAD52 homolog (S. cerevisiae); RAD52 homolog; RAD52_HUMAN; Recombination protein RAD52 ; Recombination protein RAD52; Rhabdomyosarcoma antigen MU RMS 40.23

Target Background

The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.