Recombinant Human DnaJ homolog subfamily A member 2 (DNAJA2)

Uniprot Id

O60884

Target Species

Human

Target Name

DNAJA2

Target Full Name

DnaJ homolog subfamily A member 2

Target Function

Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).

Target Subcellular Location

Membrane; Lipid-anchor.

Target Synonyms

Cell cycle progression 3 protein; Cell cycle progression restoration gene 3 protein; CPR 3; CPR3; Dj3; DJA 2; DJA2; DnaJ (Hsp40) homolog subfamily A member 2; DNAJ; DnaJ heat shock protein family (Hsp40) member A2; DnaJ homolog subfamily A member 2; DNAJA 2; Dnaja2; DNJ 3; Dnj3; DNJA2_HUMAN; HIRA interacting protein 4; HIRA-interacting protein 4; HIRIP 4; HIRIP4; OTTHUMP00000164136; PRO3015; RDJ 2; RDJ2; Renal carcinoma antigen NY REN 14; Renal carcinoma antigen NY-REN-14

Target Background

The protein encoded by this gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain. The product of this gene works as a cochaperone of Hsp70s in protein folding and mitochondrial protein import in vitro.