Recombinant Human DnaJ homolog subfamily B member 2 (DNAJB2)

Uniprot Id

P25686

Target Species

Human

Target Name

DNAJB2

Target Full Name

DnaJ homolog subfamily B member 2

Target Function

Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins. Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins.

Target Involvement

Distal spinal muscular atrophy, autosomal recessive, 5 (DSMA5)

Target Subcellular Location

[Isoform 2]: Cytoplasm. Nucleus.; [Isoform 1]: Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side.

Target Tissue Specificity

More abundantly expressed in neocortex, cerebellum, spinal cord and retina where it is expressed by neuronal cells (at protein level). Detected at much lower level in non-neuronal tissues including kidney, lung, heart, skeletal muscle, spleen and testis (

Target Research Area

Signal Transduction

Target Synonyms

DNAJB2; HSJ1; HSPF3DnaJ homolog subfamily B member 2; Heat shock 40 kDa protein 3; Heat shock protein J1; HSJ-1