Recombinant Human Dual specificity protein kinase CLK2 (CLK2), Truncated

Uniprot Id

P49760

Target Species

Human

Target Name

CLK2

Target Full Name

Dual specificity protein kinase CLK2

Target Function

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN.

Target Subcellular Location

Nucleus.; [Isoform 1]: Nucleus. Nucleus speckle.; [Isoform 2]: Nucleus speckle.

Target Protein Families

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, Lammer subfamily

Target Tissue Specificity

Endothelial cells. Expressed in androgen-dependent prostate cancer cells.

Target Research Area

Cell Biology

Target Synonyms

CDC like kinase 2; CDC-like kinase 2; CLK 2; CLK kinase; CLK2; Clk2 Scamp3; CLK2_HUMAN; Dual specificity protein kinase CLK2; hCLK 2; hCLK2; Tu52