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Recombinant Human Dual specificity protein kinase CLK3 (CLK3)

ACP23134

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Specifications

Cat.No	ACP23134	Target Name	CLK3
Target Synonyms	CDC like kinase 3; CDC-like kinase 3; CLK3; CLK3_HUMAN; Dual specificity protein kinase CLK3; PHCLK3; PHCLK3/152	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-490
Protein Length	Full Length of Isoform 1	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	P49761

Background Information

Uniprot Id

P49761
Target Species

Human
Target Name

CLK3
Target Full Name

Dual specificity protein kinase CLK3
Target Function

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Target Subcellular Location

[Isoform 1]: Nucleus. Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome.; [Isoform 2]: Nucleus speckle. Note=Co-localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles.
Target Protein Families

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, Lammer subfamily
Target Tissue Specificity

Endothelial cells.
Target Synonyms

CDC like kinase 3; CDC-like kinase 3; CLK3; CLK3_HUMAN; Dual specificity protein kinase CLK3; PHCLK3; PHCLK3/152

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Recombinant Human Dual specificity protein kinase CLK3 (CLK3)

Specifications

Immunogen Information

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