Recombinant Human E3 ubiquitin-protein ligase NRDP1 (RNF41)

Cat.No	ACP03177	Target Name	RNF41
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	1-317aa	Mol Weight	62.9kDa
Protein Length	Full length	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP03177

Target Name

RNF41

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-317aa

Mol Weight

62.9kDa

Protein Length

Full length

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9H4P4

Background Information

Uniprot Id

Q9H4P4
Target Species

Human
Target Name

RNF41
Target Full Name

E3 ubiquitin-protein ligase NRDP1
Target Function

Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control.
Target Tissue Specificity

Detected in ovary, testis and prostate.
Target Research Area

Cell Biology
Target Synonyms

4930511A05Rik; 4933415P08Rik; E3 ubiquitin protein ligase NRDP1; E3 ubiquitin-protein ligase NRDP1; Fetal Liver RING finger protein; FLRF; MGC45228; Neuregulin receptor degradation protein 1; NRDP1; RING finger protein 41; rnf41; RNF41_HUMAN; SBBI03

Recombinant Human E3 ubiquitin-protein ligase NRDP1 (RNF41)

Specifications

Immunogen Information

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