Recombinant Human E3 ubiquitin-protein ligase RLIM (RLIM)

Uniprot Id

Q9NVW2

Target Species

Human

Target Name

RLIM

Target Full Name

E3 ubiquitin-protein ligase RLIM

Target Function

E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.

Target Involvement

Mental retardation, X-linked 61 (MRX61)

Target Subcellular Location

Nucleus.

Target Protein Families

RNF12 family

Target Tissue Specificity

Expressed in many tissues.

Target Synonyms

E3 ubiquitin-protein ligase RLIM; LIM domain-interacting RING finger protein; R-LIM; Renal carcinoma antigen NY-REN-43; RING finger LIM domain-binding protein; RING finger protein 12; RLIM; RNF12; RNF12_HUMAN

Target Background

The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified.