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| Cat.No | ACP01513 | Target Name | ZNRF3 |
|---|---|---|---|
| Target Synonyms | (RING finger protein 203)(RING-type E3 ubiquitin transferase ZNRF3)(Zinc/RING finger protein 3) | Form | Liquid or Lyophilized powder |
| Expression System | Yeast | Expression Range | 56-219aa |
| Mol Weight | 19.7 kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9ULT6 |
|---|
Uniprot Id
Q9ULT6
Target Species
Human
Target Name
ZNRF3
Target Full Name
E3 ubiquitin-protein ligase ZNRF3
Target Function
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Protein Families
ZNRF3 family
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
ZNRF3; KIAA1133; RNF203; E3 ubiquitin-protein ligase ZNRF3; EC 2.3.2.27; RING finger protein 203; RING-type E3 ubiquitin transferase ZNRF3; Zinc/RING finger protein 3
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