Recombinant Human Echinoderm microtubule-associated protein-like 4 (EML4), Truncated

Uniprot Id

Q9HC35

Target Species

Human

Target Name

EML4

Target Full Name

Echinoderm microtubule-associated protein-like 4

Target Function

Essential for the formation and stability of microtubules (MTs). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs. Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression.

Target Subcellular Location

Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center. Midbody.

Target Protein Families

WD repeat EMAP family

Target Synonyms

EML4; C2orf2; Echinoderm microtubule associated protein like 4; Echinoderm microtubule-associated protein-like 4; ELP 120; ELP120; EMAL4_HUMAN; EMAP 4; EMAP-4; EMAP4; EML 4; eml4; Restrictedly overexpressed proliferation associated protein; Restrictedly overexpressed proliferation-associated protein; Ropp 120; ROPP120

Target Background

This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants.