Recombinant Human Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3), Truncated

Uniprot Id

O14638

Target Species

Human

Target Name

ENPP3

Target Full Name

Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Target Function

Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has also alkaline phosphodiesterase activity.

Target Subcellular Location

Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein. Secreted.

Target Protein Families

Nucleotide pyrophosphatase/phosphodiesterase family

Target Tissue Specificity

Detected on bile ducts in liver, and in blood serum (at protein level). Detected in prostate and uterus. Detected on basophils, but not neutrophils.

Target Synonyms

Alkaline phosphodiesterase I; ARHR2; B10; CD203c; CD203c antigen ; dJ1005H11.3 (phosphodiesterase I/nucleotide pyrophosphatase 3); dJ914N13.3 (phosphodiesterase I/nucleotide pyrophosphatase 3); E NPP 3; E-NPP 3; Ectonucleotide pyrophosphatase/phosphodiesterase 3; Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; ENPP3; ENPP3_HUMAN; gp130RB13 6; gp130RB136; M6S1; NPP1; NPP3; NPPase; NPPS; Nucleotide pyrophosphatase; PC 1; PC-1; PCA1; PD Ibeta; PD-Ibeta; PDNP1; PDNP3; Phosphodiesterase I beta; Phosphodiesterase I/nucleotide pyrophosphatase 3; phosphodiesterase i/nucleotide pyrophosphatase beta

Target Background

The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene.