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| Cat.No | ACP12376 | Target Name | SH3GL2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-352 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q99962 |
|---|
Uniprot Id
Q99962
Target Species
Human
Target Name
SH3GL2
Target Full Name
Endophilin-A1
Target Function
Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
Target Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein. Early endosome. Cell junction, synapse, presynapse.
Target Protein Families
Endophilin family
Target Tissue Specificity
Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.
Target Synonyms
bA335L15.1 (SH3 domain GRB2 like 2); CNSA2; EEN B1; EEN-B1; Endophilin 1; Endophilin A1; Endophilin A1 BAR domain; Endophilin-1; Endophilin-A1; FLJ20276; FLJ25015; OTTHUMP00000021084; SH3 domain containing GRB2 like protein 2; SH3 domain GRB2 like 2; SH3 domain protein 2A; SH3 domain-containing GRB2-like protein 2; SH3D2A; SH3G2_HUMAN; Sh3gl2; Sh3p4; SH3PA
Target Background
Enables identical protein binding activity. Involved in negative regulation of blood-brain barrier permeability; negative regulation of gene expression; and negative regulation of protein phosphorylation. Located in perinuclear region of cytoplasm.
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