Recombinant Human Enoyl-CoA delta isomerase 2, mitochondrial (ECI2)

Uniprot Id

O75521

Target Species

Human

Target Name

ECI2

Target Full Name

Enoyl-CoA delta isomerase 2

Target Function

Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates.

Target Subcellular Location

[Isoform 1]: Mitochondrion.; [Isoform 2]: Peroxisome matrix.

Target Protein Families

Enoyl-CoA hydratase/isomerase family

Target Tissue Specificity

Abundant in heart, skeletal muscle and liver. Expressed in CD34(+) T-cells and CD34(+) bone marrow cells.

Target Synonyms

2-trans-enoyl-CoA isomerase; ACBD2 ; acyl Coenzyme A binding domain containing 2 ; D2-enoyl-CoA isomerase; D3; D3 D2 enoyl CoA isomerase; DBI related protein 1 ; DBI-related protein 1; delta(2)-enoyl-CoA isomerase; Delta(3); Delta(3) delta(2) enoyl CoA isomerase; Diazepam-binding inhibitor-related protein 1; Dodecenoyl CoA isomerase; Dodecenoyl-CoA isomerase; DRS 1 ; DRS-1; DRS1 ; Eci2; ECI2_HUMAN; Enoyl-CoA delta isomerase 2; HCA88 ; Hepatocellular carcinoma associated antigen 88; Hepatocellular carcinoma-associated antigen 88; mitochondrial; pECI; Peroxisomal 3; Peroxisomal 3,2-trans-enoyl-CoA isomerase; Peroxisomal D3 D2 enoyl CoA isomerase; Renal carcinoma antigen NY REN 1 ; Renal carcinoma antigen NY-REN-1

Target Background

This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described.