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The generation of the recombinant Human STOM protein typically includes the following steps: synthesizing the recombinant plasmid containing the gene encoding the Human STOM protein (1-288aa), transforming the recombinant plasmid into e.coli cells, selecting the positive e.coli cells, and culturing the positive e.coli cells for protein expression. The protein is equipped with a N-terminal 6xHis-SUMO tag. After expression, affinity purification is employed to isolate and purify the recombinant STOM protein from the cell lysate. Denaturing SDS-PAGE is utilized to resolve the resulting recombinant Human STOM protein, revealing a purity level exceeding 90%.
The generation of the recombinant Human STOM protein typically includes the following steps: synthesizing the recombinant plasmid containing the gene encoding the Human STOM protein (1-288aa), transforming the recombinant plasmid into e.coli cells, selecting the positive e.coli cells, and culturing the positive e.coli cells for protein expression. The protein is equipped with a N-terminal 6xHis-SUMO tag. After expression, affinity purification is employed to isolate and purify the recombinant STOM protein from the cell lysate. Denaturing SDS-PAGE is utilized to resolve the resulting recombinant Human STOM protein, revealing a purity level exceeding 90%.
| Cat.No | ACP03624 | Target Name | STOM |
|---|---|---|---|
| Target Synonyms | BND7 ; EPB7 ; EPB72; Erythrocyte band 7 integral membrane protein; Erythrocyte membrane protein band 7.2 (stomatin) ; Erythrocyte surface protein band 7.2; Protein 7.2b; STOM; STOM_HUMAN; Stomatin | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-288aa |
| Mol Weight | 47.7kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P27105 |
|---|
Uniprot Id
P27105
Target Species
Human
Target Name
STOM
Target Full Name
Stomatin
Target Function
Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.
Target Subcellular Location
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor; Cytoplasmic side. Membrane raft. Melanosome. Cytoplasmic vesicle.
Target Protein Families
Band 7/mec-2 family
Target Tissue Specificity
Detected in erythrocytes (at protein level). Widely expressed.
Target Research Area
Neuroscience
Target Synonyms
BND7 ; EPB7 ; EPB72; Erythrocyte band 7 integral membrane protein; Erythrocyte membrane protein band 7.2 (stomatin) ; Erythrocyte surface protein band 7.2; Protein 7.2b; STOM; STOM_HUMAN; Stomatin
Target Background
This gene encodes a member of a highly conserved family of integral membrane proteins. The encoded protein localizes to the cell membrane of red blood cells and other cell types, where it may regulate ion channels and transporters. Loss of localization of the encoded protein is associated with hereditary stomatocytosis, a form of hemolytic anemia. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants.
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