Recombinant Human Exosome complex component RRP41 (EXOSC4)

Cat.No	ACP10296	Target Name	EXOSC4
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	2-245	Protein Length	Full Length of Mature Protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP10296

Target Name

EXOSC4

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

2-245

Protein Length

Full Length of Mature Protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9NPD3

Background Information

Uniprot Id

Q9NPD3
Target Species

Human
Target Name

EXOSC4
Target Full Name

Exosome complex component RRP41
Target Function

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs.
Target Subcellular Location

Cytoplasm. Nucleus, nucleolus. Nucleus.
Target Protein Families

RNase PH family
Target Synonyms

EXOS4_HUMAN; EXOSC 4; EXOSC4; Exosome complex component RRP41; Exosome complex exonuclease RRP41; Exosome component 4; Exosome component Rrp41; FLJ20591; hRrp41p; p12A; Ribosomal RNA processing protein 41; Ribosomal RNA-processing protein 41; RRP 41; RRP41; RRP41A; Rrp41p; SKI 6; SKI6; Ski6p
Target Background

Enables mRNA 3'-UTR AU-rich region binding activity. Involved in nucleic acid metabolic process and positive regulation of cell growth. Acts upstream of or within defense response to virus. Located in cytosol; nucleoplasm; and transcriptionally active chromatin. Part of exosome (RNase complex).

Recombinant Human Exosome complex component RRP41 (EXOSC4)

Specifications

Immunogen Information

Inquire Recombinant Human Exosome complex component RRP41 (EXOSC4) Now

Related Products