Recombinant Human Fibroblast growth factor 17 (FGF17)

Uniprot Id

O60258

Target Species

Human

Target Name

FGF17

Target Full Name

Fibroblast growth factor 17

Target Function

Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development.

Target Involvement

Hypogonadotropic hypogonadism 20 with or without anosmia (HH20)

Target Subcellular Location

Secreted.

Target Protein Families

Heparin-binding growth factors family

Target Tissue Specificity

Preferentially expressed in the embryonic brain.

Target Synonyms

FGF 13; FGF 17; FGF-17; FGF13; Fgf17; FGF17_HUMAN; Fibroblast growth factor 17; HH20

Target Background

This gene encodes a member of the fibroblast growth factor (FGF) family. Member of the FGF family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is expressed during embryogenesis and in the adult cerebellum and cortex and may be essential for vascular growth and normal brain development. Mutations in this gene are the cause of hypogonadotropic hypogonadism 20 with or without anosmia. Alternate splicing results in multiple transcript variants.