Recombinant Human Fibronectin type III domain-containing protein 5 (FNDC5), Truncated,Yeast

Uniprot Id

Q8NAU1

Target Species

Human

Target Name

FNDC5

Target Full Name

Fibronectin type III domain-containing protein 5

Target Function

Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Peroxisome membrane; Single-pass type I membrane protein.; [Irisin]: Secreted.

Target Tissue Specificity

Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen.

Target Research Area

Cell Biology

Target Synonyms

Fibronectin type III domain containing 5; Fibronectin type III domain-containing protein 5; Fibronectin type III repeat containing protein 2; Fibronectin type III repeat-containing protein 2; FNDC 5; Fndc5; FNDC5_HUMAN; FRCP2; irisin

Target Background

This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants.