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| Cat.No | ACP01667 | Target Name | FILIP1L |
|---|---|---|---|
| Target Synonyms | (130 kDa GPBP-interacting protein)(90 kDa GPBP-interacting protein)(Protein down-regulated in ovarian cancer 1)(DOC-1) | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-200aa |
| Mol Weight | 27.6 kDa | Protein Length | Partial of Isoform 3 |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q4L180 |
|---|
Uniprot Id
Q4L180
Target Species
Human
Target Name
FILIP1L
Target Full Name
Filamin A-interacting protein 1-like
Target Function
Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature.
Target Subcellular Location
Cytoplasm. Membrane. Nucleus.
Target Protein Families
FILIP1 family
Target Tissue Specificity
Expressed in endothelial cells, colon and colon cancers. In the colon, expressed in the vasculature and muscularis mucosa. In colon cancer, strongly expressed in tumor stroma and the vasculature (at protein level). Expressed in ovarian epithelial cells. D
Target Research Area
Cancer
Target Synonyms
130 kDa GPBP-interacting protein; 90 kDa GPBP-interacting protein; COL4A3BPIP; DOC-1; DOC1; Downregulated in ovarian cancer 1 81 kDa isoform; FIL1L_HUMAN; Filamin A-interacting protein 1-like; FILIP1L; GIP130; GIP130a; GIP130b; GIP130c; GIP90; GPBP interacting protein 90; Protein down-regulated in ovarian cancer 1
Target Background
Predicted to be located in cytoplasm; membrane; and nucleus.
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