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| Cat.No | ACP01770 | Target Name | FSHR |
|---|---|---|---|
| Target Synonyms | Follitropin receptor | Form | Liquid or Lyophilized powder |
| Expression System | Mammalian cell | Expression Range | 18-366aa |
| Mol Weight | 68.8 kDa | Protein Length | Partial |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P23945 |
|---|
Uniprot Id
P23945
Target Species
Human
Target Name
FSHR
Target Full Name
Follicle-stimulating hormone receptor
Target Function
G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
Target Involvement
Ovarian dysgenesis 1 (ODG1); Ovarian hyperstimulation syndrome (OHSS)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
G-protein coupled receptor 1 family, FSH/LSH/TSH subfamily
Target Tissue Specificity
Sertoli cells and ovarian granulosa cells.
Target Research Area
G-protein coupled receptor, Neuroscience
Target Synonyms
Follicle stimulating hormone receptor; Follicle stimulating hormone receptor isoform 1; Follicle-stimulating hormone receptor; Follitropin receptor; FSH receptor; FSH-R; Fshr; FSHR_HUMAN; FSHRO; LGR1; MGC141667; MGC141668; ODG1; ovarian dysgenesis 1
Target Background
The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants.
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