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The fusion tag N-terminal 6xHis tag gene was added to the gene sequence corresponding to the mammalian cell of the human GLP1R protein to form the recombinant DNA. The recombinant DNA was cloned into the expression vector and then transfected into the mammalian cell for expression. Following purification, the product is the recombinant human GLP1R protein carrying N-terminal 6xHis tag. The SDS-PAGE assessed the purity of this recombinant GLP1R protein up to 90%. It had an apparent molecular weight of approximately 18 kDa. This recombinant GLP1R protein may find use in neuroscience research.GLP1R is a gene presented on chromosome 6 providing instructions for making a protein called glucagon-like peptide 1 receptor in human and belongs to G-protein coupled receptor 2 family. GLP1R is a receptor protein expressed in beta cells of the pancreas and neurons of the brain. It is involved in the control of blood sugar level by enhancing insulin secretion. Studies have reported that GLP1R is a significant therapeutic target for small molecule drug discovery given the therapeutic impact of peptide agonists in the diabetes sphere.
The fusion tag N-terminal 6xHis tag gene was added to the gene sequence corresponding to the mammalian cell of the human GLP1R protein to form the recombinant DNA. The recombinant DNA was cloned into the expression vector and then transfected into the mammalian cell for expression. Following purification, the product is the recombinant human GLP1R protein carrying N-terminal 6xHis tag. The SDS-PAGE assessed the purity of this recombinant GLP1R protein up to 90%. It had an apparent molecular weight of approximately 18 kDa. This recombinant GLP1R protein may find use in neuroscience research.GLP1R is a gene presented on chromosome 6 providing instructions for making a protein called glucagon-like peptide 1 receptor in human and belongs to G-protein coupled receptor 2 family. GLP1R is a receptor protein expressed in beta cells of the pancreas and neurons of the brain. It is involved in the control of blood sugar level by enhancing insulin secretion. Studies have reported that GLP1R is a significant therapeutic target for small molecule drug discovery given the therapeutic impact of peptide agonists in the diabetes sphere.
| Cat.No | ACP03700 | Target Name | Glp1r |
|---|---|---|---|
| Target Synonyms | GLP1R; Glucagon-like peptide 1 receptor; GLP-1 receptor; GLP-1-R; GLP-1R | Form | Liquid or Lyophilized powder |
| Expression System | Mammalian cell | Expression Range | 24-145aa |
| Mol Weight | 18.3kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P43220 |
|---|
Uniprot Id
P43220
Target Species
Human
Target Name
GLP1R
Target Full Name
Glucagon-like peptide 1 receptor
Target Function
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
G-protein coupled receptor 2 family
Target Research Area
Neuroscience, Cardiovascular
Target Synonyms
GLP1R; Glucagon-like peptide 1 receptor; GLP-1 receptor; GLP-1-R; GLP-1R
Target Background
This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.
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