Recombinant Human Glutamine-rich protein 1 (QRICH1)

Uniprot Id

Q2TAL8

Target Species

Human

Target Name

QRICH1

Target Full Name

Transcriptional regulator QRICH1

Target Function

Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress. Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway. ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR. May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability. Upregulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver. Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth

Target Subcellular Location

Nucleus. Cytoplasm. Cell membrane.

Target Synonyms

FLJ20259 protein; Glutamine-rich protein 1; QRIC1_HUMAN; QRICH1