Recombinant Human Glutathione S-transferase A4 (GSTA4)

Cat.No	ACP00394	Target Name	GSTA4
Target Synonyms	GST class-alpha member 4;Glutathione S-transferase A4-4	Form	Liquid or Lyophilized powder
Expression System	Mammalian cell	Expression Range	1-222aa
Mol Weight	54.6 kDa	Protein Length	Full length
Purity	Greater than 95% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP00394

Target Name

GSTA4

Target Synonyms

GST class-alpha member 4;Glutathione S-transferase A4-4

Form

Liquid or Lyophilized powder

Expression System

Mammalian cell

Expression Range

1-222aa

Mol Weight

54.6 kDa

Protein Length

Full length

Purity

Greater than 95% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	O15217

Background Information

Uniprot Id

O15217
Target Species

Human
Target Name

GSTA4
Target Full Name

Glutathione S-transferase A4
Target Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE).
Target Subcellular Location

Cytoplasm.
Target Protein Families

GST superfamily, Alpha family
Target Tissue Specificity

Expressed at a high level in brain, placenta, and skeletal muscle and much lower in lung and liver.
Target Research Area

Cell Biology, Metabolism
Target Synonyms

DKFZp686D21185; Glutathione S alkyltransferase A4; Glutathione S aralkyltransferase A4; Glutathione S aryltransferase A4; Glutathione S transferase A4 4; Glutathione S transferase A4; Glutathione S transferase alpha 4 ; Glutathione S-transferase A4; Glutathione S-transferase A4-4; Glutathione transferase A4 4; GST class alpha member 4; GST class-alpha member 4; GSTA4 4; GSTA4; GSTA4_HUMAN; GTA4; OTTHUMP00000016624; OTTHUMP00000016625; S (hydroxyalkyl)glutathione lyase A4
Target Background

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis.

Recombinant Human Glutathione S-transferase A4 (GSTA4)

Specifications

Immunogen Information

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