Recombinant Human Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1), Truncated

Uniprot Id

O43292

Target Species

Human

Target Name

GPAA1

Target Full Name

Glycosylphosphatidylinositol anchor attachment 1 protein

Target Function

Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate.

Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Target Tissue Specificity

Ubiquitously expressed in fetal and adult tissues. Expressed at higher levels in fetal tissues than adult tissues.

Target Synonyms

GPAA1; GAA1; Glycosylphosphatidylinositol anchor attachment 1 protein; GPI anchor attachment protein 1; GAA1 protein homolog; hGAA1

Target Background

Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains.