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| Cat.No | ACP00529 | Target Name | LARGE1 |
|---|---|---|---|
| Target Synonyms | Acetylglucosaminyltransferase-like 1A;Glycosyltransferase-like protein;LARGE xylosyl- and glucuronyltransferase 1 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 32-756aa |
| Mol Weight | 91.6 kDa | Protein Length | Partial |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O95461 |
|---|
Uniprot Id
O95461
Target Species
Human
Target Name
LARGE1
Target Full Name
Xylosyl- and glucuronyltransferase LARGE1
Target Function
Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). Phosphorylated O-mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide
Target Involvement
Muscular dystrophy-dystroglycanopathy congenital with mental retardation B6 (MDDGB6); Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A6 (MDDGA6)
Target Subcellular Location
Golgi apparatus membrane; Single-pass type II membrane protein.
Target Protein Families
Glycosyltransferase 49 family; Glycosyltransferase 8 family
Target Tissue Specificity
Ubiquitous. Highest expression in heart, brain and skeletal muscle.
Target Research Area
Cancer
Target Synonyms
LARGE1; KIAA0609; LARGE; LARGE xylosyl- and glucuronyltransferase 1; Acetylglucosaminyltransferase-like 1A; Glycosyltransferase-like protein [Includes: Xylosyltransferase LARGE; Beta-1,3-glucuronyltransferase LARGE; ]
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