Recombinant Human Guanine nucleotide-binding protein G (I)/G (S)/G (T) subunit beta-3 (GNB3)

Cat.No	ACP24021	Target Name	GNB3
Target Synonyms	G protein beta 3 subunit; GBB3_HUMAN; GNB3; GNB3 guanine nucleotide binding protein (G protein)	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-340
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP24021

Target Name

GNB3

Target Synonyms

G protein beta 3 subunit; GBB3_HUMAN; GNB3; GNB3 guanine nucleotide binding protein (G protein)

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-340

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P16520

Background Information

Uniprot Id

P16520
Target Species

Human
Target Name

GNB3
Target Full Name

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
Target Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Target Involvement

Night blindness, congenital stationary, 1H (CSNB1H)
Target Protein Families

WD repeat G protein beta family
Target Synonyms

G protein beta 3 subunit; GBB3_HUMAN; GNB3; GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3; GTP binding regulatory protein beta 3 chain; Guanine nucleotide binding protein (G protein) beta polypeptide 3; Guanine nucleotide binding protein G; Guanine nucleotide binding protein G(I)/G(S)/G(T) beta subunit 3; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Hypertension associated protein; IG; SG; Transducin beta chain 3; Tsubunit beta 3
Target Background

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Recombinant Human Guanine nucleotide-binding protein G (I)/G (S)/G (T) subunit beta-3 (GNB3)

Specifications

Immunogen Information

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