Recombinant Human Guanine nucleotide-binding protein G (i) subunit alpha-3 (GNAI3)

Cat.No	ACP04255	Target Name	GNAI3
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	1-354aa	Mol Weight	44.5kDa
Protein Length	Full length	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP04255

Target Name

GNAI3

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-354aa

Mol Weight

44.5kDa

Protein Length

Full length

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P08754

Background Information

Uniprot Id

P08754
Target Species

Human
Target Name

GNAI3
Target Full Name

Guanine nucleotide-binding protein G(i) subunit alpha-3
Target Function

Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels. Stimulates the activity of receptor-regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.
Target Involvement

Auriculocondylar syndrome 1 (ARCND1)
Target Subcellular Location

Cytoplasm. Cell membrane; Lipid-anchor. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Target Protein Families

G-alpha family, G(i/o/t/z) subfamily
Target Research Area

Cell Cycle
Target Synonyms

87U6; FLJ26559; G protein alpha inhibiting 3; G(i) alpha 3 ; G(i) alpha-3; GNAI3; GNAI3_HUMAN; Guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 ; Guanine nucleotide binding protein G(k) alpha subunit; Guanine nucleotide-binding protein G(k) subunit alpha; OTTHUMP00000013368
Target Background

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway.

Recombinant Human Guanine nucleotide-binding protein G (i) subunit alpha-3 (GNAI3)

Specifications

Immunogen Information

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