Recombinant Human Guanylate kinase (GUK1)

Uniprot Id

Q16774

Target Species

Human

Target Name

GUK1

Target Full Name

Guanylate kinase

Target Function

Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors. It may also have a role in the survival and growth progression of some tumors. In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine.

Target Subcellular Location

Photoreceptor inner segment. Cytoplasm, cytosol.

Target Protein Families

Guanylate kinase family

Target Tissue Specificity

Widely expressed.

Target Research Area

Cancer

Target Synonyms

ATP:GMP phosphotransferase; FLJ42686; FLJ43710; GMK; GMP kinase; Guanylate kinase; GUK1; KGUA_HUMAN

Target Background

The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene.