Recombinant Human Hepatocyte cell adhesion molecule (HEPACAM), Truncated

Uniprot Id

Q14CZ8

Target Species

Human

Target Name

HEPACAM

Target Full Name

Hepatic and glial cell adhesion molecule

Target Function

Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation.

Target Involvement

Leukoencephalopathy, megalencephalic, with subcortical cysts, 2A (MLC2A); Leukoencephalopathy, megalencephalic, with subcortical cysts, 2B (MLC2B)

Target Subcellular Location

Cytoplasm. Membrane; Single-pass type I membrane protein; Cytoplasmic side. Note=In MCF-7 breast carcinoma and hepatic Hep 3B2.1-7 and Hep-G2 cell lines, localization of HEPACAM is cell density-dependent. In well spread cells, localized to punctate structures in the perinuclear membrane, cytoplasm, and at cell surface of protusions. In confluent cells, localized predominantly to the cytoplasmic membrane, particularly in areas of cell-cell contacts. Colocalizes with CDH1.

Target Synonyms

FLJ25530; GlialCAM; HECAM_HUMAN; HEPACAM; Hepatocyte cell adhesion molecule; Protein hepaCAM

Target Background

The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene.