Recombinant Human Homeobox protein Hox-A2 (HOXA2)

Uniprot Id

O43364

Target Species

Human

Target Name

HOXA2

Target Full Name

Homeobox protein Hox-A2

Target Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Target Involvement

Microtia, hearing impairment, and cleft palate (MHICP); Microtia with or without hearing impairment (MCRT)

Target Subcellular Location

Nucleus.

Target Protein Families

Antp homeobox family, Proboscipedia subfamily

Target Research Area

Others

Target Synonyms

AI324701; homeo box A2; homeobox A2; Homeobox protein Hox-1K; Homeobox protein Hox-A2; Hox-1.11; HOX1.11; HOX1K; Hoxa-2; Hoxa11; HOXA2; HXA2_HUMAN; MGC151482; MGC151484; RATHOX111A

Target Background

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development.